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Over-the-counter supplements touted to support prostate health are popular, and supposedly help prevent and manage symptoms of an enlarged prostate (benign prostate hyperplasia). Some of the ingredients are said to protect against prostate cancer or slow its growth. While research has explored supplements' role in prostate health and some had positive results, the findings are far from conclusive. A better dietary option for prostate health is to follow a plant-based diet like the Mediterranean or DASH diet.

Many people have misconceptions about avoiding heart disease. One involves the use of over-the-counter fish oil capsules, which do not prevent heart disease in healthy people. Another relates to confusion about the ideal blood pressure targets in older adults. Some people are misinformed about the implications of a family history of heart disease, while others may be confused about the differences in heart attack symptoms between men and women.

Digestive enzyme supplements are promoted to fix problems like bloating, gas, and bowel irregularity. However, for most people, there's little evidence that they help. Doctors may prescribe enzyme pills for people who can't make enough digestive enzymes because of a health condition.

A 2022 study found that low blood levels of vitamin D (under 25 nanomoles per liter) were linked with higher risks of dementia. People can boost vitamin D levels from diet, supplements, or sun exposure.

Ten years of data suggest that AREDS2 supplements are associated with a reduced risk of macular degeneration progression without any increase in lung cancer risk, according to a follow-up study published online June 2, 2022, by JAMA Ophthalmology.

An estimated 3.2% of adults ages 50 or older have very low B₁₂ levels, and up to 20% may have borderline deficiency. Aging is often the cause. Other causes include taking heartburn medications; eating a diet that does not include animal products; weight loss surgery; or autoimmune diseases that attack the stomach lining or gastrointestinal tract. It’s a good idea for older adults to take a B₁₂ supplement of 2.8 micrograms daily to ward off B₁₂ deficiency. People who have very low levels of B₁₂ may need to take a much higher dose or get B₁₂ injections.

One in three Americans takes a daily multivitamin even though research shows this doesn't provide any meaningful health benefits for most people. And because of the way supplements are regulated, some supplements make claims that have no evidence behind them.

Nutrient deficiencies are uncommon with a broad and varied diet. But aging, hormonal factors, or diet can leave women short of four key vitamins and minerals: vitamin D, iron, vitamin B₁₂, and calcium. Various tests can reveal nutrient deficiencies, including blood panels. Vitamin D and fish oil supplements may help prevent autoimmune diseases. Multivitamins are usually unnecessary, except in cases where age, pregnancy, digestive challenges, or certain medications interfere with the ability to get adequate nutrition.

The number of people taking large amounts of melatonin (more than 5 milligrams per day) is at an all-time high. However, the amount in a supplement can be significantly higher than what the label shows. This can cause people to take too much, especially since many use melatonin regularly.