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Taking supplements that contain high levels of biotin (vitamin B₇) can lead to falsely low or falsely high results on a troponin test, a blood test used to diagnose heart attacks.

A small randomized trial in 2023 found that taking two 250-mg capsules of curcumin four times a day was as effective at relieving dyspepsia symptoms as taking one daily 20-mg dose of the heartburn medication omeprazole (Prilosec, Zegerid).

Despite statements like "promotes heart health" on the labels of fish oil supplements, multiple randomized trials show no evidence of heart-related benefits from using these products. In addition, manufacturing methods might make the products either useless or even harmful. The supplements do provide omega-3 fatty acids, but people can get these essential fats by eating two servings of fatty fish weekly or following a vegetarian diet rich in healthy oils, nuts, and seeds.

Ads for products that promise to supercharge the body's immune system make claims that sound too good to be true. But do these products actually work? 

The general consensus is that healthy people who eat right need a vitamin or mineral supplement only if they have a diagnosed vitamin or mineral deficiency. Still, multivitamins may provide a safety net to fill dietary nutrition gaps even for people who mostly eat healthy. Studies have shown that taking multivitamins as prescribed usually doesn't cause any serious issues, and many over-the-counter brands are relatively inexpensive. Some people also view taking a daily multivitamin as another way to support a healthy lifestyle.

Increasing evidence suggests that people who take a daily multivitamin pill have a lower risk of cognitive decline compared with people who don't take multivitamins. In particular, two randomized controlled trials published in the spring of 2023 found that people older than age 60 who take a multivitamin are less likely to experience a slight age-related cognitive decline, at least over the next three years, compared to those taking a placebo. The benefit appeared to be particularly true for people who had cardiovascular disease.