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Brain iron deficiency should be one of the first considerations when treating restless legs syndrome (RLS). But many doctors don't know that iron deficiency is one cause of RLS and don't test for it, particularly in men, in whom iron deficiency is uncommon.

High-dose niacin (vitamin B₃) is no longer recommended to improve cholesterol and triglyceride levels. Different forms of niacin, such as niacinamide (nicotinamide), are sold as supplements; the potential benefits and risks remain unclear.

The demand for semaglutide (Wegovy, Ozempic) and similar weight-loss drugs has renewed interest in the dietary supplement berberine. Some people say berberine suppresses appetite and promotes weight loss, but no rigorous evidence supports that claim.

A 2024 study found that dietary supplements of galantamine—which is used to treat Alzheimer's symptoms—had an inaccurate amount of the plant extract listed on the label, ranging from less than 2% to 110% of the labeled quantity.

A 2024 randomized controlled trial provides more evidence that taking a daily multivitamin pill offers protection against cognitive decline. The study involved more than 5,000 people (ages 60 or older). Some took a daily multivitamin pill. Others took a placebo. After two years and tests measuring cognitive ability before and after the study period, people who took the vitamins showed slower cognitive decline than people who took a placebo. This was seen consistently in all groups of people.

While most people get enough vitamins and minerals from a regular diet, they may benefit from taking a daily multivitamin supplement. These are inexpensive, are considered safe, and may help maintain brain health.