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Many people who start a cholesterol drug wind up discontinuing its use. That's because statins, a common type of medication that lowers cholesterol, have both real and perceived side effects, such as muscle aches. To stay on a statin, one can ease into use with a low-dose or an alternate-day dose strategy, consider if other medications or circumstances are to blame for discomfort, try gentle stretching, take coenzyme Q₁₀, or replenish low vitamin D levels. Another strategy is to take a non-statin drug that lowers cholesterol.

Statin therapy can help lower the risk of developing new plaques in the arteries and having a heart attack, although the effect may not show up on coronary artery calcium scans that measure the amount of calcium in the walls of the heart's arteries.

Evidence suggests that people who recover from COVID-19 have an increased risk for developing new health problems, including heart attacks, high blood pressure, diabetes, high cholesterol, muscle inflammation, blood clots that travel to the lungs, strokes from clots or hemorrhages, or psychosis. This is in addition to permanent damage that can result from having COVID, including damage to the lungs, heart, kidneys, brain, or other organs; and debilitating fatigue, difficulty thinking, and other symptoms that make it hard to function normally at work or at home.