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High-dose niacin (vitamin B₃) is no longer recommended to improve cholesterol and triglyceride levels. Different forms of niacin, such as niacinamide (nicotinamide), are sold as supplements; the potential benefits and risks remain unclear.

According to a 2024 review, the ketogenic (keto) diet—which is high in fat and protein and low in carbohydrates—doesn't meet standards for a healthy diet and may not be safe for some people with heart disease.

Women with high-risk strains of human papillomavirus—a well-known cause of cervical cancer—may face four times the risk of dying from cardiovascular disease, according to a 2024 study.

A 2023 study suggests that long-term exposure to transportation noise from cars, trucks, trains, and planes is associated with an increased risk of cardiovascular disease.

A heart rate below 60 beats per minute, called bradycardia, is fairly common in people older than 70. The most common permanent cause is age-related degenerative changes in the heart's conduction system. Previous heart problems, including a heart attack or heart surgery, make the problem more likely. Medical issues including sleep apnea, hypothyroidism, and certain medications can also cause bradycardia. People experiencing a low heart rate and symptoms such as feeling dizzy, lightheaded, fatigued, or breathless should seek medical care right away.

A thoracic aortic aneurysm (a weakened area in the wall of the upper section of the aorta) may require surgical repair if it grows too large. Aneurysms in the area called the descending aorta can sometimes be repaired with a less invasive endovascular technique.

A normal pulse rate is between 60 and 100 beats per minute. Possible causes of an elevated pulse include fever, anemia, anxiety, or an overactive thyroid. Other possibilities include too much caffeine, decongestants, or being out of shape.

Standard definitions consider a healthy body mass index (BMI), a calculation based on a person's height and weight, as between 18.5 and 24.9. Studies have found that a higher BMI increases risk for heart disease, diabetes, and some types of cancer. However, even if their BMI does not fall into the category of overweight, people who gain five or more pounds may be at risk for health problems, especially if the weight gain is belly fat. The best approach is a combination of aerobic exercise, strength training, and a healthy diet.

People who lose weight with a portion-controlled diet and exercise may be able to reverse their diabetes. When that happens, their risk of heart disease and kidney disease declines, according to a 2024 study.

Every year, an estimated 600,000 people in the United States develop a blood clot deep inside the leg, known as deep-vein thrombosis. These clots usually develop in the lower leg, thigh, or pelvis but occasionally the arm. The affected area may be tender or painful, swollen, red or discolored, and warm to the touch. If a clot breaks free and travels to a lung, it can cause a pulmonary embolism. Symptoms of a pulmonary embolism include difficulty breathing that happens suddenly, a fast or irregular heartbeat, coughing up blood, and chest pain or discomfort, which usually worsens with a deep breath or coughing.