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Standard definitions consider a healthy body mass index (BMI), a calculation based on a person's height and weight, as between 18.5 and 24.9. Studies have found that a higher BMI increases risk for heart disease, diabetes, and some types of cancer. However, even if their BMI does not fall into the category of overweight, people who gain five or more pounds may be at risk for health problems, especially if the weight gain is belly fat. The best approach is a combination of aerobic exercise, strength training, and a healthy diet.

People who lose weight with a portion-controlled diet and exercise may be able to reverse their diabetes. When that happens, their risk of heart disease and kidney disease declines, according to a 2024 study.

Every year, an estimated 600,000 people in the United States develop a blood clot deep inside the leg, known as deep-vein thrombosis. These clots usually develop in the lower leg, thigh, or pelvis but occasionally the arm. The affected area may be tender or painful, swollen, red or discolored, and warm to the touch. If a clot breaks free and travels to a lung, it can cause a pulmonary embolism. Symptoms of a pulmonary embolism include difficulty breathing that happens suddenly, a fast or irregular heartbeat, coughing up blood, and chest pain or discomfort, which usually worsens with a deep breath or coughing.

New guidelines for managing atrial fibrillation focus on lifestyle habits to prevent and control the disorder. One recommendation is for people to limit alcohol to one drink per day, or ideally less. Another is for people who are overweight or obese to lose weight, either by striving for a body mass index no greater than 27 or by shedding at least 10% of their body weight. The guidelines also suggest that people get three to four hours of exercise per week. And people with afib who snore should consider getting tested for sleep apnea.

A 2024 study suggests doing a workout that's a combination of aerobics and strength training might reduce cardiovascular risk factors just as effectively as a workout that consists of aerobics only.

A calcium score is a good indicator of how much plaque is inside the heart's arteries. Treatments can replace cholesterol in plaque with scar tissue, which contains calcium and produces a higher calcium score, but this stabilized plaque lowers heart attack risk.

Treatments for angina include medications to lower LDL cholesterol to very low levels to help reduce artery-narrowing plaque. Drugs that slow the heart rate and widen arteries can improve symptoms.

Clinical trials are under way using gene therapy to treat inherited cardiovascular conditions, including familial hypercholesterolemia (one form of abnormally high cholesterol), hypertrophic cardiomyopathy (a type of heart muscle disease), and transthyretin amyloid cardiomyopathy (a form of heart failure resulting from amyloid deposits). But challenges remain in developing and delivering these therapies.

Tiny mesh tubes called stents, used to prop open heart arteries, can relieve stable angina (chest pain with exertion or emotional stress) in many people with coronary artery disease. But this treatment—which carries a risk of complications and a high cost—should be reserved only for people who don't get relief from drug therapy. Stents do not prevent future heart attacks or improve survival compared with drug therapy. Angina usually results from arteries that are more than 70% blocked, but most heart attacks occur in arteries that are narrowed by only about 40% or less but harbor plaque that ruptures without warning. The resulting blood clot blocks blood flow, triggering a heart attack.

The weight-loss drug semaglutide is the first obesity treatment shown to help people live longer and have fewer cardiovascular problems. Developed as a drug for type 2 diabetes, semaglutide was first marketed as Ozempic; a higher-dose version for weight loss is called Wegovy. But because the drug is so popular, it can be hard to find, and it might not be covered by insurance.