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Two main complications can occur with coronary stents: the gradual renarrowing of the area inside the stent, known as restenosis, and the formation of clots inside the stent, called stent thrombosis.

Mental stress ischemia occurs when emotional stress causes a decline in blood flow to the heart. The condition, which affects about one in six people with heart disease, may more than double a person's risk of heart attack. Mental stress ischemia appears to be caused in part by changes in the wall and inner lining of the heart's smallest blood vessels. Known as microvascular disease, this problem tends to be more prevalent in women. In contrast, a more common cause of chest pain is narrowing of the large arteries of the heart.

Stimulant medications, which are usually prescribed to treat attention deficit disorder in children, are being prescribed increasingly to older adults. These drugs may cause a short-term spike in the risk of heart-related problems, including heart attacks, strokes, and arrhythmias. Dietary supplements that promise weight loss or better physical or mental performance may contain prohibited, unlisted, and potentially dangerous stimulants.

Broken heart syndrome—an uncommon condition linked to severe emotional or physical stress that occurs mostly in women—may be more common than previously thought. The increase in diagnoses may reflect heightened awareness of all forms of heart disease in women. The condition may result from the surge of adrenaline that affects the heart's muscle cells and blood vessels, causing the heart's left ventricle to temporarily change shape. The heart resembles a Japanese clay pot used to trap an octopus, called a tako-tsubo, which is why broken heart syndrome was originally dubbed takotsubo cardiomyopathy.

A study published online Aug. 26, 2021, by The Lancet found that blood pressure treatment protects against heart attacks, strokes, and other major cardiovascular disease problems in people up to age 85 and possibly older. For people younger than 75, the study confirmed that people taking blood pressure medicines had 10% to 20% fewer cardiovascular disease problems. For people 75 to 84, there still was a 10% reduction. For people older than 85, the results were mixed, but there still appeared to be a benefit from blood pressure treatment.

A doctor's serious health threat prompts reflection on the power of spirituality, the value of mindfulness practice, and acknowledgment of mortality as a motivator to reassess one's priorities.

Exercise may help to reverse some types of heart damage. Not only can workouts prevent heart problems, but it may help to improve conditions that may raise risk for cardiovascular events. A 2021 study, for example, showed that a yearlong exercise program helped improve heart health in people who were at increased risk for heart failure.

Treating people who have low levels of vitamin D with supplements may reduce their risk for heart attacks and death from any cause.

A draft guideline from a national panel of experts recommends that people without heart disease who are 60 and older should not take low-dose aspirin to prevent a heart attack or stroke.