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A small randomized trial in 2023 found that taking two 250-mg capsules of curcumin four times a day was as effective at relieving dyspepsia symptoms as taking one daily 20-mg dose of the heartburn medication omeprazole (Prilosec, Zegerid).

Virtually everyone carries the bacteria Clostridioides difficile, or C. diff. But half a million Americans a year develop a serious C. diff infection due to a gut microbiome imbalance. It disproportionately strikes people in hospitals and nursing homes, and can recur repeatedly.

"Regular" bowel movements can mean something different for each person. Some people have a bowel movement once or twice daily; for others, it's once or twice weekly. People should see a doctor if they notice a dramatic change in bowel habits or other symptoms, including fatigue, pain, unintended weight loss, bloody stool, or a change in stool consistency. People can promote digestion by maintaining a toileting schedule, heeding their body's signals, and using a toilet stool.

Following a plant-based eating pattern and cutting back on highly processed foods can help promote a more diverse, healthier microbiome. A healthy gut microbiome may decrease inflammation that promotes heart disease. Most fruits, vegetables, beans, and whole grains are good sources of prebiotic fiber, which is broken down by gut bacteria to create short-chain fatty acids. These fatty acids are linked to lower inflammation and reductions in other heart disease risk factors.

Eating two peeled kiwifruits per day may help ease constipation, according to a small randomized trial published in 2023. The effectiveness of eating kiwifruits was slightly greater than that of using a daily fiber supplement such as Metamucil or Fiberall.

A 2023 study suggests that women who have used menopausal hormone therapy are significantly more likely to develop gastroesophageal reflux disease (GERD).

In the US population as a whole, deaths from colon cancer have been declining, but in people under 50 that rate has increased. Most major medical organizations recommend screening beginning at age 45 for people at average risk.